C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 493/22 (2006.01) A61K 31/352 (2006.01) A61K 31/366 (2006.01) A61P 11/12 (2006.01)
Patent
CA 2539590
Disclosed are compounds that are derivatives of brevetoxin, or PbTx, pharmaceutical formulations comprising the compounds, and methods of regulating mucus transport in a cell, treating mucociliary dysfunction and diseases related to decreased mucus transport, wherein the compounds are of the Formula (I), and Formula (III): Formula (I), Formula (III) wherein R, R1, R2, R3, A, n, and Y are as defined herein for each compound.
La présente invention concerne des composés qui sont des dérivés de brevetoxine, ou PbTx, des préparations pharmaceutiques comprenant ces composés ainsi que des méthodes permettant de réguler le transport du mucus dans une cellule, de traiter un dysfonctionnement mucociliaire et des maladies associées à l'affaiblissement du transport du mucus. Les composés sont représentés par la formule (I), et la formule (III):, dans ces formules, R, R¿1?, R¿2?, R¿3?, A, n, et Y sont tels que définis pour chaque composé.
Abraham William M.
Baden Daniel G.
Bourdelais Andrea J.
Osler Hoskin & Harcourt Llp
University Of North Carolina At Wilmington
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