Polyethylene glycol derivatives, modified peptides and...

Details Polyethylene glycol derivatives, modified peptides and... Polyethylene glycol derivatives, modified peptides and...

C - Chemistry, Metallurgy

12

N

167/103, 195/35,

C12N 9/96 (2006.01) A61K 47/48 (2006.01) C07K 1/06 (2006.01) C07K 1/107 (2006.01) C08G 65/323 (2006.01) C08G 65/329 (2006.01) C08G 65/334 (2006.01)

Patent

CA 1335722

Disclosed are polyethylene glycol derivatives of the formula: Image (I) (wherein R represents a lower alkyl and n represents a positive integer which renders the average molecular weight of the polyethylene glycol moiety about 1,000 to 12,000), peptides modified by the polyethylene glycol derivatives and methods for production thereof. The polyethylene glycol derivatives (I) are useful for modifying guanidino groups in peptides. The peptides modified by the polyethylene glycol derivative (I) are extremely stable, are considerably delayed in biological clearance (i.e. the durability is extended) and exhibit their physiological activities effectively over the long period.

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