Polyethylene glycol derivatives, modified peptides and...

Details Polyethylene glycol derivatives, modified peptides and... Polyethylene glycol derivatives, modified peptides and...

C - Chemistry, Metallurgy

12

N

C12N 9/00 (2006.01) A61K 38/17 (2006.01) A61K 47/48 (2006.01) C07C 49/86 (2006.01) C07K 1/107 (2006.01) C07K 14/435 (2006.01) C08G 65/32 (2006.01) C08G 65/329 (2006.01) C08G 65/331 (2006.01) C08G 65/334 (2006.01) C12N 9/96 (2006.01)

Patent

CA 2017541

27103-48 ABSTRACT A polyethylene glycol derivative of the formula Image wherein R1 and R2 are the same or different and each represents a lower alkyl and m and n are same or different and each represents a positive integer which ren- ders the average molecular weight of the polyethylene glycol moiety about 1,000 to 12,000, a peptide modified by the polyethylene glycol derivative and a method for production thereof are described. The polyethylene glycol derivative (I) is capable of modifying guanidino groups in peptides. The thereby modified peptides are extremely stable, are con- siderably delayed in biological clearance (i.e. the durability is extended) and exhibit their physiological activities effectively over a long period of time.

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