Polyethylene glycol/polycation block copolymers

C - Chemistry – Metallurgy – 08 – G

Patent

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Details

C08G 69/48 (2006.01) A61K 9/127 (2006.01) A61K 47/34 (2006.01) A61K 48/00 (2006.01)

Patent

CA 2524907

A block copolymer comprising a poly(ethylene glycol) segment and a poly(amino acid derivative) segment having at least one specified type of amine residue in its side chain. Further, there is provided a polyion complex produced from the block copolymer and a polynucleotide, etc. This block copolymer is useful as an in vivo delivery carrier for active substances such as DNA.

L'invention concerne un copolymère séquencé comprenant un segment de polyéthylèneglycol et un segment poly(dérivé d'acide aminé) comportant au moins un type spécifique de résidu aminé dans sa chaîne latérale. L'invention concerne également un complexe de type polyionique produit à partir de ce copolymère séquencé et d'un polynucléotide, etc. Ce copolymère séquencé est utilisé comme un substrat pour l'administration in vivo de substances actives, telles que l'ADN.

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