Polyethylene oxide-based films and drug delivery systems...

A - Human Necessities – 61 – K

Patent

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Details

A61K 9/70 (2006.01) A61K 47/34 (2006.01) A61K 47/38 (2006.01)

Patent

CA 2544776

The invention relates to the film products and methods of their preparation that demonstrate a non-self-aggregating uniform heterogeneity. Desirably, the films disintegrate in water and may be formed by a controlled drying process, or other process that maintains the required uniformity of the film. The films contain a polymer component, which includes polyethylene oxide optionally blended with hydrophilic cellulosic polymers. Desirably, the films also contain a pharmaceutical and/or cosmetic active agent with no more than a 10% variance of the active agent pharmaceutical and/or cosmetic active agent per unit area of the film.

L'invention porte sur des films et leurs procédés de préparation leur conférant une hétérogénéité uniforme non autoagrégatrice. Il est souhaitable que les films se désintègrent dans l'eau et soient obtenus par un procédé de séchage contrôlé en assurant l'uniformité voulue. Un tel film consiste en un composant polymérique d'oxyde de polyéthylène, facultativement mélangé à des polymères cellulosiques hydrophiles. Il est également souhaitable qu'il contienne un agent à activité pharmaceutique et/ou cosmétique dont la variance ne dépasse pas 10 % par unité de surface.

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