Polyethyleneglycol-modified lipid compounds and uses thereof

Details Polyethyleneglycol-modified lipid compounds and uses thereof Polyethyleneglycol-modified lipid compounds and uses thereof

C - Chemistry, Metallurgy

12

N

C12N 15/88 (2006.01) A61K 9/127 (2006.01) A61K 31/7088 (2006.01) A61K 47/44 (2006.01) A61K 47/48 (2006.01) A61K 48/00 (2006.01) C07C 235/06 (2006.01) C07C 271/16 (2006.01) C07C 275/06 (2006.01) C07C 321/14 (2006.01) C07H 21/00 (2006.01)

Patent

CA 2551022

Polyethyleneglycol (PEG) dialkyloxypropyl (DAA) lipid conjugates are disclosed which have increased stability over commonly used PEG-lipids conjuguates. Liposomal compositions, stabilized plasmid-lipid particles (SPLP) and stabilized nucleic acid-lipid particles (SNALP) comprising said PEG-DAA conjuguates, for delivery of a bioactive agent to a cell or patient are described.

L'invention concerne des conjugués lipidiques polyéthylèneglycol-dialkyloxypropyle (PEG-DAA) possédant une stabilité accrue par rapport aux conjugués PEG-lipides généralement utilisés. L'invention concerne également des compositions liposomales, des particules plasmides-lipides stabilisées (SPLP) et des particules acides nucléiques-lipides stabilisées (SNALP) comprenant lesdits conjugués PEG-DAA, ces compositions et ces particules servant à introduire un agent bioactif dans une cellule ou à administrer cet agent bioactif à un patient.

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