C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 5/078 (2006.01) A61K 38/05 (2006.01) C07K 5/06 (2006.01) C07K 5/065 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2233698
This invention relates to polyfluoroalkyl tryptophan tripeptides and to compositions containing them. The compounds are highly selective thrombin inhibitors which provide anticoagulant effects useful in the treatment of thrombin conditions and in preventing the coagulation of stored whole blood and blood products.
La présente invention a pour objet des tripeptides de polyfluoroalkyle tryptophane et les compositions les contenant. Ces composés sont des inhibiteurs de thrombine très sélectifs dont les effets anticoagulants sont utiles dans le traitement d'états liés à la thrombine et dans la prévention de la coagulation de produits sanguins et de sang total stockés.
Broersma Robert J.
Burkhart Joseph P.
Malikayl J. Antony
Peet Norton P.
Aventis Pharmaceuticals Inc.
Hoechst Marion Roussel Inc.
Osler Hoskin & Harcourt Llp
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