Polyhemoglobin stabilized by purine derivatives and glutathione

Details Polyhemoglobin stabilized by purine derivatives and glutathione Polyhemoglobin stabilized by purine derivatives and glutathione

C - Chemistry, Metallurgy

07

K

C07K 14/805 (2006.01) A61K 35/14 (2006.01) A61K 38/42 (2006.01) C07K 1/36 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2072081

A hemoglobin preparation is disclosed which comprises purified hemoglobin (preferably bovine), crosslinked intramolecularly with periodate-oxidized ATP(o- ATP) and intermoleculary with periodate-oxidized adenosine (o-adenosine), and combined with reduced glutathione (GSH). The compound is useful as a blood substitute because (1) it has prolonged intravascular persistence and can sustain plasma volume, (2) it has low oxygen affinity and can work as a physiological oxygen carrier, and (3) it has vasodilator activity and can reduce the vasoconstriction that follows hemorrhage.

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