Polyhydroxy phenols and their use in binding p-selectin

Details Polyhydroxy phenols and their use in binding p-selectin Polyhydroxy phenols and their use in binding p-selectin

C - Chemistry, Metallurgy

07

C

C07C 69/96 (2006.01) A61K 31/198 (2006.01) A61K 47/18 (2006.01) A61K 47/48 (2006.01) C07C 227/14 (2006.01) C07C 229/16 (2006.01)

Patent

CA 2527141

Polyhydroxy phenols, which are non-peptidic mimetics of galloyl peptides, and a process for the preparation of gallic acid derivatives using a gallic-acid providing moiety are provided as well as polyhydroxy phenol-containing pharmaceutical and nutraceutical compositions. The use of polyhydroxy phenols as a medicament and especially for the manufacture of a medicament for the prevention, treatment or diagnosis of a disease or a condition, wherein P- selectin is involved, is provided. The same compounds can also be used as targeting tools to P-selectin expressing cells or tissues in a composition, further comprising an active compound in a vehicle.

L'invention concerne des polyhydroxy phénols qui sont des mimétiques non peptidiques de peptides galloyle, et un procédé de préparation de dérivés d'acide gallique au moyen d'un groupe fonctionnel produisant de l'acide gallique, ainsi que des compositions pharmaceutiques et nutraceutiques contenant des polyhydroxy phénols. L'invention concerne également l'utilisation de polyhydroxy phénols comme médicament et, notamment, pour la fabrication d'un médicament pour la prévention, le traitement ou le diagnostic d'une maladie ou d'un état impliquant la P-sélectine. Les mêmes composés peuvent aussi servir d'outils de ciblage de cellules ou tissus exprimant la P-sélectine dans une composition, comprenant en outre un composé actif dans un excipient.

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