Polyhydroxybutyrate and polyphosphate membranes with channels

B - Operations – Transporting – 01 – D

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Details

B01D 69/12 (2006.01) A61K 9/127 (2006.01) C12Q 1/02 (2006.01) G01N 27/40 (2006.01) G01N 33/52 (2006.01) G01N 33/68 (2006.01)

Patent

CA 2176361

Lipid bilayers which incorporate poly-3-hydroxybutyrate/polyphosphate ion channels. The ion channels are preferably purified polyhydroxybutyrate polyphosphate complexes extracted from organisms or prepared from the individual constituents which have been size selected. The bilayers are useful for testing the affect of various molecules and ions on the channel which correlates to the in vivo result. The bilayers are useful for transporting the channels into cells or other bilayers.

La présente invention concerne des membranes bicouches lipidiques incorporant des canaux ioniques de poly-3-hydroxybutyrate et du poly-3-polyphosphate. Les canaux ioniques sont de préférence des complexes purifiés de polyhydroxybutyrate-polyphosphates extraits d'organismes ou préparés à partir de constituants individuels sélectionnés en fonction de leur taille. Les membranes bicouches s'utilisent pour vérifier l'influence de molécules et ions divers sur le canal en cas de corrélation entre l'influence et le résultat in vivo. Les membranes bicouches conviennent avantageusement au transport des canaux vers l'intérieur des cellules ou l'intérieur d'autres membranes bicouches.

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