Polyinosinic acid-polycytidylic acid-based adjuvant

Details Polyinosinic acid-polycytidylic acid-based adjuvant Polyinosinic acid-polycytidylic acid-based adjuvant

A - Human Necessities

61

K

A61K 39/39 (2006.01)

Patent

CA 2605583

The present invention provides a polynucleotide adjuvant composition and methods of use in eliciting an immune response. The present invention also provides an immunogenic composition comprising the polynucleotide adjuvant composition together with an antigen (e.g., as in a vaccine). The adjuvant compositions of the invention have particular physical properties (e.g., molecular weight, concentration, and pH) which address the need for a safe adjuvant for eliciting an enhanced immune response. The present invention further contemplates methods of use of such adjuvant compositions, particularly in eliciting an immune response to an antigenic compound.

Une composition d'adjuvant polynucléotide et ses procédés d'utilisation afin d'obtenir une réponse immunitaire. Une composition immunogène comprend la composition d'adjuvant polynucléotide et un antigène, notamment dans un vaccin. Les compositions d'adjuvant de cette invention présentent des propriétés particulières physiques, notamment un poids moléculaire, une teneur et un pH, qui répondent au besoin d'obtenir un adjuvant sûr pour obtenir une réponse immune améliorée. Les procédés d'utilisation de telles compositions, notamment pour l'obtention d'une réponse immune à un composé antigène.

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