Polyionic microencapsulation

Details Polyionic microencapsulation Polyionic microencapsulation

C - Chemistry, Metallurgy

12

N

167/166

C12N 11/04 (2006.01) A61K 9/16 (2006.01) A61K 9/50 (2006.01) B01J 13/02 (2006.01) B01J 13/08 (2006.01) B01J 13/20 (2006.01) C12N 11/08 (2006.01)

Patent

CA 1245984

POLYIONIC MICROENCAPSULATION Abstract of the Disclosure A new process has been developed for damage-free encapsulation of a variety of core materials including viable cells. The core material is suspended in an aqueous solution of a polymeric material containing cationic groups such as an aminated glucopolysaccharide. A temporary matrix is formed by gelling droplets of the suspension with a divalent or multivalent anion. The temporary matrix is permanently cross-linked with a polymeric material containing plural anionic groups, e.g., polyaspartic or polyglutamic acid, to form a semipermeable membrane, The interior of the microcapsule may be resolublized by subjecting the capsule to a solution of low molecular weight cations. The process produces microcapsules which are not sticky, do not clump and allow viable cell growth and prolifera- tion. -1-

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