C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 498/18 (2006.01) A61K 31/436 (2006.01) A61P 37/06 (2006.01)
Patent
CA 2343880
Host cells comprising recombinant vectors encoding the FK-520 polyketide synthase and FK-520 modification enzymes can be used to produce the FK-520 polyketide. Recombinant DNA constructs comprising one or more FK-520 polyketide synthase domains, modules, open reading frames, and variants thereof can be used to produce recombinant polyketide synthases and a variety of different polyketides with application as pharmaceutical and veterinary products.
Il est possible d'utiliser des cellules hôtes comprenant des vecteurs de recombinaison codant la polykétide FK-520 synthase et des enzymes de modification de FK-520 pour produire le polykétide FK-520. Il est également possible de se servir de produits d'ADN de recombinaison comprenant un ou plusieurs domaines, modules, cadres et variants de polykétide FK-520 synthase pour produire des polykétide synthases de recombinaison ainsi que toute une gamme de polykétides différents entrant dans l'élaboration de produits pharmaceutiques et vétérinaires.
Chu Daniel
Khosla Chaitan
Reeves Christopher
Santi Daniel
Wu Kai
Fetherstonhaugh & Co.
Kosan Biosciences Inc.
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