Polyketides and their synthesis

Details Polyketides and their synthesis Polyketides and their synthesis

C - Chemistry, Metallurgy

12

N

C12N 15/52 (2006.01) C12N 9/10 (2006.01) C12P 17/06 (2006.01) C12P 19/62 (2006.01)

Patent

CA 2331764

A polyketide synthase ("PKS") of Type I is a complex multienzyme includ-ing a loading domain linked to a multi-plicity of extension domains. The first extension module receives an acyl starter unit from the loading domain and each ex-tension module adds a further ketide unit which may undergo processing (e.g. reduc-tion). We have found that the Ksq domain possessed by some PKS's has decarboxy-lating activity, e.g. generating (substituted) acyl from (substituted) malonyl. The CLF domain of type II PKS's has similar activ-ity. By inserting loading modules includ-ing such domains into PKS's not normally possessing them it is possible to control the starter units used.

Une polycétide synthase ("PKS") de type I est un complexe multienzymatique comprenant un domaine de chargement lié à une multiplicité de domaines d'extension. Le premier module d'extension reçoit une unité de démarrage d'acyle à partir du domaine de chargement, et chaque module d'extension ajoute une autre unité de cétide qui peut subit un traitement (par ex. une réduction). On a observé que le domaine Ksq que possèdent certaines PKS présente une activité de décarboxylation, par exemple, en générant de l'acyle (substitué) à partir du malonyle (substitué). Le domaine CLF des PKS de type II présente une activité semblable. Il est possible de contrôler les unités de démarrage utilisées en insérant des modules de chargement comprenant des domaines de ce type dans les PKS qui en sont normalement dépourvues.

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