Polyketides and their synthesis

Details Polyketides and their synthesis Polyketides and their synthesis

C - Chemistry, Metallurgy

12

N

C12N 15/54 (2006.01) A61K 31/70 (2006.01) C07H 17/08 (2006.01) C12N 9/10 (2006.01) C12N 15/52 (2006.01) C12N 15/63 (2006.01) C12P 17/06 (2006.01) C12P 19/62 (2006.01)

Patent

CA 2335523

A polyketide synthase ("PKS") of Type I is a complex multienzyme including a loading domain linked to a multiplicity of extension domains. Ths first extension module receives an acyl starter unit from the loading domain and each extension module adds a further ketide unit which may undergo processing (e.g. reduction). We have found that the Ksq domain possessed by some PKS's has decarboxylating activity, e.g. generating (substituted) acyl from (substituted) malonyl. The CLF domain of type II PKS's has similar activity. By inserting loading modules including such domains into PKS's not normally possessing them it is possible to control the starter units used.

Une polycétide synthase ("PKS") de type I est un complexe multienzymatique comprenant un domaine de chargement lié à une multiplicité de domaines d'extension. Le premier module d'extension reçoit une unité de démarrage d'acyle à partir du domaine de chargement, et chaque module d'extension ajoute une autre unité de cétide qui peut subit un traitement (par ex. une réduction). On a observé que le domaine Ksq que possèdent certaines PKS présente une activité de décarboxylation, par exemple, en générant de l'acyle (substitué) à partir du malonyle (substitué). Le domaine CLF des PKS de type II présente une activité semblable. Il est possible de contrôler les unités de démarrage utilisées en insérant des modules de chargement comprenant des domaines de ce type dans les PKS qui en sont normalement dépourvues.

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