Polyketides and their synthesis

Details Polyketides and their synthesis Polyketides and their synthesis

C - Chemistry, Metallurgy

12

N

C12N 15/52 (2006.01) C07D 309/30 (2006.01) C07D 313/00 (2006.01) C07H 17/08 (2006.01) C12N 1/21 (2006.01) C12N 9/00 (2006.01) C12N 9/10 (2006.01) C12P 17/06 (2006.01) C12P 19/62 (2006.01)

Patent

CA 2419538

Biosyntheses of compounds whereof at least portions are polyketides produced by means of polyketide synthase (PKS) enzyme complexes are carried out after specific alterations have been made within the acyltransferase (AT) domains of the PKSs. Particular motifs in or near the substrate binding pocket are disclosed, such that alterations therein affect substrate specificity.

On procède à la biosynthèse de composés, dont certaines parties au moins sont des polycétides produits par des complexes enzymatiques de polycétide synthase (PKS), après avoir effectué des modifications spécifiques dans les domaines acyltransférase (AT) de ces PKS. L'invention porte également sur des motifs particuliers présents dans la poche de fixation du substrat ou près de celle-ci, les modifications apportées ayant une incidence sur la spécificité du substrat.

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