Polymer-based antimicrobial agents, methods of making said...

A - Human Necessities – 01 – N

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A01N 59/16 (2006.01) A01N 25/02 (2006.01) A01P 1/00 (2006.01) A61K 33/38 (2006.01) A61L 2/18 (2006.01)

Patent

CA 2669334

The present invention relates to antimicrobial agents, methods for the production of these agents, and the use of these agents. The antimicrobial agent of the present invention includes a water-soluble polymer and oligodynamic metal ions which interact with counter-ions of the polymer such that the metal ions are bound to corresponding counter-ions. The water-soluble polymer controls a sustained release of the metal ions. The oligodynamic metal ions preferably include small size metal particles (e.g., nano-sized silver particles) that interact to the water-soluble polymer as well as metal ions derived from one or more water-soluble oligodynamic metal compositions (e.g., metal sulfates and/or metal nitrates). The agent may also include one or more acids, including organic acids (such as sulfates, carboxylic acids, amines, hydroxyls, nitrates, and phosphates) and/or non-organic acids (such as boric acid and dioctylborate).

L'invention concerne des agents antimicrobiens, des procédés de production associés, ainsi que l'utilisation de ces agents. L'agent antimicrobien selon l'invention contient un polymère hydrosoluble et des ions métalliques oligodynamiques qui interagissent avec des contre-ions du polymère, de sorte que les ions métalliques soient liés aux contre-ions correspondants. Le polymère hydrosoluble régule la libération prolongée des ions métalliques. Les ions métalliques oligodynamiques contiennent de préférence des particules métalliques de petite taille (par exemple des nanoparticules d'argent) qui interagissent avec le polymère hydrosoluble, ainsi que des ions métalliques issus d'au moins une composition métallique oligodynamique hydrosoluble (des sulfates métalliques et/ou des nitrates métalliques, par exemple). L'agent selon l'invention peut également contenir au moins un acide, notamment des acides organiques (tels que des sulfates, des acides carboxyliques, des amines, des hydroxyles, des nitrates et des phosphates) et/ou des acides non organiques (tels que de l'acide borique et du dioctylborate).

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