C - Chemistry – Metallurgy – 08 – G
Patent
C - Chemistry, Metallurgy
08
G
C08G 63/664 (2006.01) A61K 9/107 (2006.01) A61K 38/13 (2006.01) A61K 47/30 (2006.01) A61P 37/06 (2006.01) C08G 63/08 (2006.01)
Patent
CA 2580305
The present invention is in the field of polymer-based nano-carriers for the solubilization and delivery of hydrophobic drugs, and relates to methods of making said carriers, and to pharmaceutical compositions comprising said carriers. Novel PEO-b-PCL micelles and micelles containing cyclosporine A or analogs thereof are provided as well as a novel method for making said micelles that reduces aggregation and enhances delivery, the toxicity profile and biodistribution of hydrophobic drugs.
L'invention concerne le domaine de nano-supports à base polymère servant à effectuer la solubilisation et l'application de médicaments hydrophobes, ainsi que des méthodes de préparation de ces supports et des compositions pharmaceutiques contenant ledit support. Elle concerne également de nouvelles micelles PEO-b-PCL et des micelles contenant cyclosporine A ou ses analogues et une nouvelle méthode servant à préparer ces micelles afin de limiter l'agrégation et d'augmenter la qualité d'application, le profil de toxicité et la biodistribution de médicaments hydrophobes.
Kwon Glen S.
Lavasanifar Afsaneh
Parlee Mclaws Llp
The Governors Of The University Of Alberta
Wisconsin Alumni Research Foundation
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