Polymer-bound methotrexate, a process for its preparation...

A - Human Necessities – 61 – K

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167/100, 530/13,

A61K 47/48 (2006.01) A61K 31/505 (2006.01)

Patent

CA 2009695

- 1 - Abstract of the Disclosure: Polymer-bound methotrexate, a process for its preparation and its use The crosslinking of the carboxyl groups of methotrexate or analogs with hydroxyl groups of water-soluble, biocom- patible polymers results in a pro-drug form of the active substance with good relevant properties for human anti- tumor therapy.

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