Polymer brushes for immobilizing molecules to a surface or...

Details Polymer brushes for immobilizing molecules to a surface or... Polymer brushes for immobilizing molecules to a surface or...

G - Physics

01

N

G01N 33/53 (2006.01) C08F 220/54 (2006.01) C08F 220/58 (2006.01) C08F 292/00 (2006.01) C12Q 1/68 (2006.01) G01N 33/543 (2006.01)

Patent

CA 2377739

Sensors for determining the presence and concentration of bio-molecules in a biological sample are provided in the form of polymer brushes, which comprise a substrate having a surface that is modified with a water-dispersible or water-soluble polymer segment having functional groups that bind probes. The method of synthesis of such sensors preferably includes use of controlled free radical polymerization techniques which allows for controlled architecture polymers to modify the surface of the substrate. In this manner functional groups in the polymer chain are removed from the surface, which allows for solution chemistry to be more realistically reproduced with the benefits of a solid bound probe.

L'invention concerne des capteurs destinés à déterminer la présence et la concentration de biomolécules dans un échantillon biologique sous forme de brosses polymères comprenant un substrat comportant une surface modifiée avec un segment polymère dispersable ou soluble dans l'eau présentant des groupes fonctionnels liés aux capteurs. Le procédé de synthèse de ces capteurs comprend, de préférence, l'utilisation de techniques de polymérisation d'un radical libre régulé, permettant à des polymères d'architecture régulée de modifier la surface du substrat. De cette manière, les groupes fonctionnels de la chaîne polymère sont retirés de la surface, permettant à la chimie des solutions d'être reproduite de façon plus réaliste avec les avantages d'un capteur lié solide.

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