Polymer-ceramic-hydrogel composite scaffold for...

A - Human Necessities – 61 – L

Patent

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A61L 27/44 (2006.01) A61L 27/42 (2006.01) A61L 27/54 (2006.01) A61L 27/56 (2006.01) A61L 27/58 (2006.01)

Patent

CA 2557436

This invention pertains to materials and methods relating to the biological fixation of one tissue type to another different tissue type, i.e., the fixation of cartilage to bone. A scaffold apparatus for osteochondral tissue engineering is described. The apparatus comprises regions of varying matrices which provide a functional interface between multiple tissue types. Further, a method for preparing the scaffold apparatus is provided. Methods for treating osteochondral tissue injury and cartilage degeneration using the scaffold apparatus are also described. In addition, a method for evaluating cell~mediated and scaffold-related parameters of development and maintenance of multiple tissue zones in vitro is described.

L'invention concerne des matériaux et des méthodes concernant la fixation biologique d'un type de tissu sur un autre type de tissu différent, notamment la fixation de cartilage sur un os. L'invention concerne un appareil d'ossature pour une ingénierie de tissu ostéochondral. L'appareil de l'invention comprend des zones de matrices variables fournissant une interface fonctionnelle entre plusieurs types de tissus. En outre, l'invention concerne une méthode pour préparer l'appareil d'ossature. L'invention concerne également des méthodes pour traiter une lésion tissulaire ostéochondrale et une dégénération cartilagineuse au moyen de l'appareil d'ossature de l'invention. En outre, l'invention concerne une méthode pour évaluer des paramètres médiés par des cellules et associés à l'ossature, qui sont des paramètres de développement et de maintenance de plusieurs zones tissulaires <i>in vitro</i>.

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