Polymer coated refractory particles as immunoadsorbent

Details Polymer coated refractory particles as immunoadsorbent Polymer coated refractory particles as immunoadsorbent

G - Physics

01

N

167/41, 167/44

G01N 31/00 (2006.01) G01N 33/543 (2006.01) G01T 1/00 (2006.01)

Patent

CA 1077392

ABSTRACT OF THE DISCLOSURE An immobilized immunoadsorbent for use in immunoassay and radioimmunoassay procedures includes, in a preferred form, a mass of superficially porous refractory particles having a water insoluble polymer, such as dextran, bonded thereto. The polymer in turn has bonded to it, by covalent bonds, antibodies capable of binding a specific antigen thereto and stoichiometrically releasing the bound antigen by the use of a rinsing solution which does not adversely affect the binding of the antibody to the polymer. Preferably, each of the porous particles includes an impervious core which has joined thereto sufficient layers of microparticles to form an outer porous coating on the core. Methods of forming such an immunoadsorbent and for using the same and structure for supporting the same are also disclosed.

248664

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