Polymer coating for medical devices

Details Polymer coating for medical devices Polymer coating for medical devices

A - Human Necessities

61

L

A61L 31/10 (2006.01) A61L 31/16 (2006.01)

Patent

CA 2625904

Coatings are provided in which surfaces may be activated by covalently bonding a silane derivative to the metal surface, covalently bonding a lactone polymer to the silane derivative by in situ ring opening polymerization, and depositing at least one layer of a poly(lactide-co-caprolactone) copolymer on the bonded lactone. Biologically active agents may be deposited with the poly(lactide-co- caprolactone) copolymer layers. Such coated surfaces may be useful in medical devices, in particular stents.

L'invention concerne des revêtements dans lesquels des surfaces peuvent être activées par liaison covalente d'un dérivé de silane à la surface métallique, par liaison covalente d'un polymère de lactone au dérivé de silane par polymérisation par ouverture de cycle in situ et par dépôt d'au moins une couche d'un copolymère de poly(lactide-co-caprolactone) sur la lactone liée. Des agents actifs sur le plan biologique peuvent être déposés avec les couches de copolymère de poly(lactide-co-caprolactone). De telles surfaces revêtues peuvent être utiles dans des dispositifs médicaux, notamment des stents.

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