C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/18 (2006.01) A61K 38/18 (2006.01) A61K 47/48 (2006.01) A61P 25/02 (2006.01) A61P 25/04 (2006.01) C07K 14/475 (2006.01)
Patent
CA 2514510
A dimer comprising a mutated neublastin polypeptide coupled to a polymer is disclosed. Such dimers exhibit prolonged bioavailability and, in preferred embodiments, prolonged biological activity relative to wild-type forms of neublastin.
L'invention concerne un dimère comprenant un de polypeptide de neublastine mutée couplé à un polymère. Ledit dimère possède une biodisponibilité prolongée et, dans des modes de réalisations préférés, une activité biologique prolongée par rapport aux formes de neublastine de type sauvage.
Boriack-Sjodin Paula Ann
Miller Stephan S.
Pepinsky R. Blake
Rossomando Anthony
Sah Dinah Wen-Yee
Biogen Idec Ma Inc.
Gowling Lafleur Henderson Llp
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