Polymer conjugates of neublastin and methods of using same

Details Polymer conjugates of neublastin and methods of using same Polymer conjugates of neublastin and methods of using same

C - Chemistry, Metallurgy

12

N

C12N 15/12 (2006.01) A61K 38/18 (2006.01) A61K 47/48 (2006.01) C07K 14/475 (2006.01) C07K 19/00 (2006.01) C12N 15/63 (2006.01) C12P 21/00 (2006.01) A61K 38/00 (2006.01) A61K 39/00 (2006.01)

Patent

CA 2436407

A variant neublastin polypeptide suitable for formation of a conjugate comprising the variant neublastin polypeptide coupled to a polymer containing a polyalkylene glycol moiety is disclosed. The present conjugate has prolonged bioavailability and, in preferred embodiments, prolonged biological activity relative to non-modified or wild-type forms of neublastin. The conjugates of the invention are usefully employed in therapeutic as well as non-therapeutic, e.g., diagnostic, applications.

Cette invention concerne un polypeptide de neublastine variant convenant pour la formation d'un conjugué qui renferme le polypeptide de neublastine variant couplé à un polymère renfermant une fraction de polyalkylène glycol. Ce conjugué présente une biodisponibilité prolongée et, selon des modes de réalisation préférés, une activité biologique prolongée à l'égard de formes non modifiées ou sauvages de neublastine. Les conjugués selon l'invention conviennent à des fins tant thérapeutiques que non thérapeutiques, diagnostiques par exemple.

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