Polymer conjugates of opioid antagonists

Details Polymer conjugates of opioid antagonists Polymer conjugates of opioid antagonists

A - Human Necessities

61

K

A61K 47/48 (2006.01) A61K 31/485 (2006.01)

Patent

CA 2463938

This invention provides polymer conjugates of opioid antagonists comprising a polymer, such as poly(ethylene glycol), covalently attached to an opioid antagonist. The linkage between the polymer and the opioid antagonist is preferably hydrolytically stable. The invention also includes a method of treating one or more side effects associated with the use of opioid analgesics, such as constipation, nausea, or pruritus, by administering a polymer conjugates of the invention.

L'invention se rapporte à des conjugués polymères d'antagonistes opioïdes, comprenant un polymère, tel qu'un poly(éthylèneglycol), lié par covalence à un antagoniste opioïde. La liaison entre le polymère et l'antagoniste opioïde est de préférence d'une bonne stabilité hydrolytique. L'invention concerne également une méthode permettant de traiter un ou plusieurs effets indésirables associés à l'utilisation d'analgésiques opioïdes, tels que la constipation, la nausée, ou le prurit, et ce par l'administration d'un conjugué polymère décrit dans l'invention.

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