Polymer derived from linear polyethylenimine for gene transfer

Details Polymer derived from linear polyethylenimine for gene transfer Polymer derived from linear polyethylenimine for gene transfer

C - Chemistry, Metallurgy

08

G

C08G 73/00 (2006.01) A61K 47/00 (2006.01) A61K 47/48 (2006.01) A61K 48/00 (2006.01) C08G 73/02 (2006.01) C08L 79/00 (2006.01) C08L 79/02 (2006.01)

Patent

CA 2717778

The invention relates to a static copolymer of linear polyethylenimine that comprises two monomer units of the following formulas I and II, in which R1 is a hydrogen atom or a C1-C6 alkyl radical, R2 is a hydrogen atom, a C1-C6 alkyl, aryl or aralkyl group, wherein the alkyl group is a C1-C6 one, n is a number between 1 and 99 % of the total monomers, m is a number between 1 and 99 % of the total monomers, and advantageously m + n = 100 %. The invention also relates to complexes of this copolymer with a nucleic acid, and to the use thereof in in vivo, in vitro or ex vivo gene transfection.

La présente invention concerne un copolymère statistique de polyéthylènimine linéaire comprenant les deux unités monomères de formules I et II suivantes, dans lesquels R, représente un atome d'hydrogène ou un radical alkyle en C1-C6, R2 représente un atome d'hydrogène, un groupe alkyle en C1-C6, aryle ou aralkyle, dans lequel le groupe alkyle est en C1-C6,n est un nombre compris entre 1 et 99 % des monomères totaux et m est un nombre compris entre 1 et 99 % des monomères totaux, avantageusement, m + n = 100 %. Il concerne en outre des complexes de ce copolymère avec un acide nucléique et son utilisation dans la transfection de gène in vivo, in vitro ou ex vivo.

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