Polymer-linked-bisphosphonate inhalant formulations and...

A - Human Necessities – 61 – K

Patent

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Details

A61K 47/48 (2006.01) A61K 9/12 (2006.01) A61K 9/14 (2006.01) A61K 9/72 (2006.01) A61P 19/08 (2006.01)

Patent

CA 2669406

The present invention provides for methods of administering a bisphosphonate active agent to a subject in need thereof. Aspects of the invention include administering the bisphosphonate active agent to the subject by a pulmonary route, where the bisphosphonate active agent is bonded, either directly or through an intervening linking group, to a non-peptide polymer, such that the bisphosphonate active agent is a polymer-linked-bisphosphonate active agent. Also provided are compositions for use in practicing methods according to embodiments of the invention. Methods and compositions according to embodiments of the invention find use in a variety of different applications, including but not limited to, the treatment of bone adsorption disease conditions.

La présente invention concerne des procédés d'administration d'un agent actif bisphosphonate à un sujet en ayant besoin. Les aspects de l'invention comprennent l'administration de l'agent actif bisphosphonate au sujet par voie pulmonaire, l'agent actif bisphosphonate étant lié, soit directement, soit par un groupe de liaison intermédiaire, à un polymère non peptidique, de telle sorte que l'agent actif bisphosphonate est un agent actif bisphosphonate lié à un polymère. L'invention concerne également des compositions destinées à être utilisées dans la mise en AEuvre de procédés selon les modes de réalisation de l'invention. Des procédés et des compositions selon les modes de réalisation de l'invention trouvent une utilité dans une diversité de différentes applications, comprenant, mais sans y être limitées, le traitement d'états de maladie d'adsorption osseuse.

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