C - Chemistry – Metallurgy – 08 – G
Patent
C - Chemistry, Metallurgy
08
G
C08G 81/00 (2006.01) A61K 9/107 (2006.01) A61K 33/24 (2006.01) A61K 47/34 (2006.01) A61K 49/00 (2006.01) A61P 35/00 (2006.01)
Patent
CA 2728960
The present invention provides a polymer-metal complex composite, which comprises a block copolymer capable of serving as a constituent member of a polymeric micelle and a metal complex having MRI contrast ability, accumulates in a tumor--specific manner, achieves high image contrast even in a small amount, and has reduced side effects and a long retention time in blood. The polymer-metal complex composite of the present invention comprises a block copolymer (A) represented by general formula (a) and a metal complex (B) having MRI contrast ability, wherein the composite comprises a structure in which a carboxyl anion of poly(carbo) in the copolymer (A) is attached to the metal complex (B) via a metal atom (M).
Cette invention concerne un composite polymère/complexe métallique qui comprend un copolymère séquencé pouvant servir de constituant d'une micelle polymère et un complexe métallique ayant une capacité de contraste en IRM. Le composite selon l'invention s'accumule de manière spécifique d'une tumeur, fournit une résolution de contraste élevée même en petite quantité, et a des effets secondaires réduits et un temps de rétention long dans le sang. Structure d'un composite polymère/complexe métallique comprenant un copolymère séquencé (A) représenté par la formule générale (a) et un complexe métallique (B) ayant une capacité de contraste en IRM, les anions carboxyle du poly(carbo) dans le copolymère (A) étant liés au complexe métallique (B) par des atomes métalliques (M).
Cabral Horacio
Kaida Sachiko
Kataoka Kazunori
Kumagai Michiaki
Sekino Masaki
Fetherstonhaugh & Co.
Japan Science And Technology Agency
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