A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 38/19 (2006.01) A61K 47/48 (2006.01) C07K 14/715 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2412150
The invention relates to polymer-modified bioactive synthetic chemokines and to methods for their production and use. The bioactive synthetic chemokines of the invention comprises a polymer modified polypeptide chemokine backbone. The compounds and methods or the invention are useful for the treatment of disorders involving naturally occurring chemokines, such as for the treatment of HIV and AIDS related disorders and for the treatment of asthma, allergic rhinitis, atopic dermatitis, atheroma/atherosclerosis, organ transplant rejection, and rheumatoid arthritis.
L'invention concerne des chimiokines synthétiques bioactives à polymères modifiés et des méthodes de production et d'utilisation associées. Ces chimiokines synthétiques bioactives comprennent un squelette de chimiokine de polypeptide à polymères modifiés. Les composés et méthodes selon l'invention sont utiles pour le traitement de troubles dans lesquels interviennent des chimiokines naturelles, notamment pour le traitement des troubles associés au VIH et au SIDA et pour le traitement de l'asthme, de la rhinite allergique, de la dermite atopique, de l'athérome/athérosclérose, du rejet de greffe et de la polyarthrite rhumatoïde.
Bradburne James A.
Kochendoerfer Gerd
Wilken Jill G.
Gryphon Therapeutics Inc.
Osler Hoskin & Harcourt Llp
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