Polymer stabilized neuropeptides

Details Polymer stabilized neuropeptides Polymer stabilized neuropeptides

C - Chemistry, Metallurgy

07

K

C07K 14/665 (2006.01) A61K 47/48 (2006.01) A61P 25/04 (2006.01) C07K 5/107 (2006.01) C07K 7/06 (2006.01)

Patent

CA 2385533

A substantially hydrophilic conjugate is provided having a peptide that is capable of passing the blood-brain barrier covalently linked to a water-soluble nonpeptidic polymer such as polyethylene glycol. The conjugate exhibits improved solubility and in vivo stability and is capable of passing the blood-brain barrier of an animal.

L'invention concerne un conjugué sensiblement hydrophile comprenant un peptide qui est capable de traverser la barrière hémato-encéphalique et qui est lié par covalence à un polymère non peptidique soluble dans l'eau tel que le polyéthylène glycol. Le conjugué présente une solubilité et une stabilité in vivo améliorées et peut traverser la barrière hémato-encéphalique chez un animal.

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