Polymerase chain reaction using metallic glass-coated microwire

H - Electricity – 01 – B

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H01B 7/18 (2006.01) A61B 13/00 (2006.01)

Patent

CA 2562428

A metallic glass-coated microwire (1) has controllable surface porosity. The porosity is achieved by etching the metallic glass-coated microwire or other shapes of glass-coated bodies with acid after annealing to produce a multi- phase glass coating. Porous metallic glass-coated microwires are found to make superior PCR machines, which find use in a variety of in vivo, biochemical, and chemical sensors. Advantageously, the PCR apparatus is smaller, less expensive to construct than conventional units. It readily carries out in vivo passive or active operations.

L'invention concerne un microfil enrobé de verre métallique présentant une porosité de surface contrôlable. Cette porosité est obtenue par l'attaque du microfil enrobé de verre métallique ou d'autres formes de corps enrobés de verre, par de l'acide, après une recuisson, pour produire un enrobage de verre multiphase. Des microfils enrobés de verre métallique poreux constituent des machines PCR supérieures, utiles dans une variété de capteurs in vivo, biochimiques et chimiques. L'appareil PCR de l'invention présente plusieurs avantages, il est plus petit et moins onéreux à construire que des unités classiques. Il permet également de réaliser facilement des opérations passives ou actives in vivo.

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