C - Chemistry – Metallurgy – 12 – Q
Patent
C - Chemistry, Metallurgy
12
Q
C12Q 1/68 (2006.01)
Patent
CA 2633524
Compositions that include polymerases with features for improving entry of nucleotide analogues into active site regions and for coordinating with the nucleotide analogues in the active site region are provided. Methods of making the polymerases and of using the polymerases in sequencing and DNA replication and amplification as well as kinetic models of polymerase activity and computer-implemented methods of using the models are also provided.
La présente invention concerne des compositions qui comprennent des polymérases avec des caractéristiques facilitant l'entrée d'analogues de nucléotides dans des régions du site actif et la coordination avec les analogues de nucléotides dans la région du site actif. L'invention concerne également des procédés de production des polymérases et de leur utilisation pour le séquençage, la réplication et l'amplification de l'ADN, ainsi qu'en tant que modèles cinétiques d'activité polymérase et des procédés informatiques d'utilisation des modèles.
Bibillo Arek
Christians Fred C.
Clark Sonya
Hanzel David K.
Lyle John
Fetherstonhaugh & Co.
Pacific Biosciences Of California Inc.
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