Polymeric artificial tear system

Details Polymeric artificial tear system Polymeric artificial tear system

A - Human Necessities

61

K

A61K 9/08 (2006.01) A61K 47/02 (2006.01) A61K 47/10 (2006.01) A61K 47/36 (2006.01)

Patent

CA 2722508

The present invention relates to artificial tear formulations and ophthalmic formulations suitable for drug delivery. The formulations comprise galactomannans such as guar or hydroxypropyl guar and a borate source such as boric acid. The for-mulations further comprise a cis-diol such as sorbitol that interferes with the cross-linking of galactomannan and borate. Optional-ly, the formulations are substantially free of divalent cations.

Linvention concerne des formulations de larme artificielle et de formulations ophtalmiques appropriées pour ladministration de médicament. Les formulations comprennent des galactomannanes tels que le guar ou lhydroxypropyl guar et une source de borate telle que lacide borique. Les formulations comprennent en outre un cis-diol tel que le sorbitol qui interfère avec la régulation du galactomannane et du borate. Eventuellement, les formulations sont sensiblement dépourvues de cations divalents.

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