Polymeric boronic acid derivatives as lipase inhibitors

Details Polymeric boronic acid derivatives as lipase inhibitors Polymeric boronic acid derivatives as lipase inhibitors

C - Chemistry, Metallurgy

08

F

C08F 20/00 (2006.01)

Patent

CA 2546696

Human obesity is a health problem affecting a significant proportion of the American population. Numerous methods of treating obesity have been developed, but all have serious drawbacks. The present invention discloses a novel class of polymers with either a sulfur atom or an electron withdrawing group between a polymer backbone and pendant aryl boronic acid group. Polymers having such an electron withdrawing group have been found to be particularly effective in inhibiting lipase in vitro and in vivo. Methods of treating obesity and reducing absorption of fat are also disclosed.

L'obésité chez l'homme est un problème de santé touchant une proportion considérable de la population américaine. De nombreuses méthodes de traitement de l'obésité ont été mises au point, mais elles représentent toutes de sérieux inconvénients. La présente invention concerne une nouvelle classe de polymères présentant soit un atome de souffre, soit un groupe de retrait d'électrons entre un squelette polymère et un groupe pendant d'aryl acide boronique. Les polymères, ayant un tel groupe de retrait d'électrons, se sont avérés être particulièrement efficaces dans l'inhibition de la lipase in vitro et in vivo. Font également l'objet de cette invention des méthodes de traitement de l'obésité et de réduction de l'absorption des graisses.

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