Polymeric carriers for release of covalently linked agents

Details Polymeric carriers for release of covalently linked agents Polymeric carriers for release of covalently linked agents

A - Human Necessities

61

K

A61K 47/48 (2006.01) A61K 31/00 (2006.01) A61K 39/395 (2006.01) A61K 47/18 (2006.01) A61K 47/42 (2006.01)

Patent

CA 2077309

Abstract A chemically defined polymeric carrier comprising a series of .alpha.- amino acids in any combination containing side chains to which diagnostic/therapeutic and chelating agents can be covalently joined through cleavable linkers either directly or covalently joined through cleavable linkers after chemical modification of the side chains. Hydrazone, disulfide, and ester linkages in any combination can be present in the polymeric carrier between the side chains of the .alpha.-amino acids and the agents. The presence of a particular covalent linkage between the side chain and the agent in the carrier is determined by the functional group present in the side chain of the .alpha.-amino acid and the functional group present in the agent. The .alpha.-amino acids with side chains to which agents do not covalently join can function as spacers to minimize interaction between bulky molecules attached to the polymeric carrier. In addition, those .alpha.-amino acids with charge or hydrophilic side chains to which agents do not covalently join can provide increased solubility to the polymeric carrier.

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