Polymeric coatings for controlled delivery of active agents

A - Human Necessities – 61 – L

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Details

A61L 29/08 (2006.01) A61L 29/16 (2006.01) A61L 31/10 (2006.01) A61L 31/16 (2006.01)

Patent

CA 2353604

Implantable medical device having a structure adapted for introduction into a patient wherein the structure is composed of a base material positioned over the structure. The implantable medical device further includes at least one composite layer of a bioactive agent and a polymer material and at least a barrier layer positioned over the composite layer and being of thickness adequate to provide a controlled release of the bioactive agent. The barrier layer being applied by a lower energy plasma polymerization process which includes placing the device with the at least one composite layer in a plasma chamber and introducing at least one monomer gas.

L'invention concerne un dispositif médical implantable présentant une structure conçue pour être introduite dans un patient. Cette structure est composée d'un matériau de base disposé sur la structure. Par ailleurs, ce dispositif médical implantable comprend au moins une couche composite composée d'un agent bioactif et d'un matériau polymère et au moins une couche barrière disposée sur ladite couche composite et présentant une épaisseur appropriée pour permettre une libération lente de l'agent bioactif. Cette couche barrière est appliquée au moyen d'un procédé de polymérisation au plasma à basse énergie qui consiste à placer le dispositif avec la couche composite dans une chambre à plasma et à introduire au moins un gaz monomère.

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