Polymeric composition, material produced thereof and their...

Details Polymeric composition, material produced thereof and their... Polymeric composition, material produced thereof and their...

C - Chemistry, Metallurgy

08

L

C08L 33/20 (2006.01) A61L 27/16 (2006.01) B01D 71/40 (2006.01) B01D 71/42 (2006.01) C08F 220/44 (2006.01) C08F 220/58 (2006.01) C08L 33/14 (2006.01) A61M 1/34 (2006.01)

Patent

CA 2500934

The invention relates to a novel polymer composition comprising at least one copolymer constituted of acrylic (AC) monomer units and of at least one water- soluble comonomer unit, which is preferably 2-acrylamido-2-methyl-propane sulfonic acid (AMPS). The composition is used to produce materials, such as membranes, film or suface coatings, that are suitable as highly tissue compatible supports for epithelial cells, such as hepatocytes. The materials are suitable to be used in a bioartificial liver, where they work as separating membrane and carrier for adhesion-dependent tissue cells. As an example it is described how selectively permeable membranes are formed by a phase inversion process from these acrylic copolymers with varying content of 2-acrylamido-2-methyl-propane sulfonic acid (AMPS) and how they interact with liver cells to construct a biohybrid organ for liver replacement.

L'invention concerne une nouvelle composition polymère comprenant au moins un copolymère constitué de motifs monomères acryliques (AC) et d'au moins un motif comonomère hydrosoluble, de préférence de l'acide 2-acrylamido-2-méthyl-propane-sulfonique (AMPS). Cette composition est utilisée pour produire des matières, telles que des membranes, des films ou des couches de surface, adaptées comme supports à haute compatibilité tissulaire pour des cellules épithéliales, telles que des hépatocytes. Lesdites matières peuvent être utilisées dans un foie bioartificiel, où elles font office de membrane séparatrice et de support pour des cellules tissulaires dépendant de l'adhésion. Selon un mode de réalisation, des membranes à perméabilité sélective sont formées par un processus d'inversion de phase à partir de ces copolymères acryliques avec une teneur variable en acide 2-acrylamido-2-méthyl-propane-sulfonique (AMPS), ces membranes coopérant avec des cellules hépatiques pour construire un organe biohybride destiné à remplacer le foie.

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