Polymeric conjugates for tissue activated drug delivery

Details Polymeric conjugates for tissue activated drug delivery Polymeric conjugates for tissue activated drug delivery

A - Human Necessities

61

K

A61K 47/48 (2006.01) A61K 47/30 (2006.01)

Patent

CA 2529972

The present invention relates to a polymeric drug conjugate with one or more biologically active agents conjugated via an enzymatically cleavable linker to either a regular repeating linear unit comprising a water soluble polymer segment and a multifunctional chemical moiety, or a branched polymer comprising two or more water soluble polymer segments each bound to a common multifunctional chemical moiety, as well as to methods of making such conjugates. The present invention is also directed to pharmaceutical compositions comprising such conjugates and to the use of such conjugates to treat pathological conditions.

L'invention concerne un conjugué médicamenteux polymère à un ou plusieurs agents biologiquement actifs conjugués par le biais d'une liaison clivable par voie enzymatique à une unité linéaire répétitif régulière comprenant un segment polymère hydrosoluble et un fragment chimique multifonctionnel ou à un polymère ramifié comprenant deux ou plusieurs segments polymères hydrosolubles, chacun lié à un fragment chimique multifonctionnel commun, ainsi que deux procédés de réalisation de tels conjugués. L'invention concerne également des compositions pharmaceutiques comprenant ces conjugués ainsi que l'utilisation de ces conjugués pour traiter des états pathologiques.

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