Polymeric derivative of cytidine metabolic antagonist

C - Chemistry – Metallurgy – 08 – G

Patent

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Details

C08G 65/08 (2006.01) A61K 38/00 (2006.01) C08G 65/333 (2006.01) C08G 69/48 (2006.01)

Patent

CA 2606939

[PROBLEMS] To provide a derivative of a cytidine metabolic antagonist which can exert a high therapeutic effect at a low dose. [MEANS FOR SOLVING PROBLEMS] A polymeric derivative of a cytidine metabolic antagonist which comprises a polymeric compound having a polyethyleneglycol moiety and a polymer moiety having a carboxyl group in a side chain and a cytidine metabolic antagonist, which has such a structure that the carboxyl group in the side chain of the polymeric compound and an amino group in the cytidine metabolic antagonist are bound together to form an amide bond.

La présente invention propose un dérivé d'un antagoniste métabolique de la cytidine capable d'exercer un effet thérapeutique puissant à faible dose. Le dérivé polymère d'un antagoniste métabolique de la cytidine comprend un composé polymère, comprenant un fragment de polyéthylène glycol et un fragment polymère avec un groupe carboxyle dans une chaîne latérale, et un antagoniste métabolique de la cytidine. La structure du dérivé est telle que le groupe carboxyle de la chaîne latérale du composé polymère et un groupe amino de l'antagoniste métabolique de la cytidine sont liés l'un à l'autre pour former une liaison amide.

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