Polymeric diffusion matrix for administration of drugs

Details Polymeric diffusion matrix for administration of drugs Polymeric diffusion matrix for administration of drugs

A - Human Necessities

61

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A61K 9/22 (2006.01) A61K 9/00 (2006.01) A61K 9/70 (2006.01) A61K 31/565 (2006.01)

Patent

CA 1163559

ABSTRACT A polymeric diffusion matrix for administering a drug is provided comprising from about 2 to about 60% of a polar plasticizer, e.g., glycerol, from about 6 to about 20% of polyvinylalcohol, from about 2 to about 10% of polyvinylpyr- rolidone, and a pharmaceutically effective amount of drug, yielding a matrix capable of sustained release of a vasodila- tor drug dispersed therein, and the balance water, the per- centages being by weight The drugs include terbutaline, ephedrine, clonidine, phenylephrine, estradiol esters, phenyl- propanolamine, and chlorpheniramine maleate.

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