Polymeric drug agents for the treatment of fibrotic disorders

Details Polymeric drug agents for the treatment of fibrotic disorders Polymeric drug agents for the treatment of fibrotic disorders

A - Human Necessities

61

K

A61K 31/79 (2006.01)

Patent

CA 2521407

Agents and methods for treatment of adhesions and fibrotic diseases, through the release of drugs that retard or inhibit fibrotic tissue production. A method for releasing fibrotic tissue-inhibiting agents from a polymer is provided. The polymer/drug combination can be applied directly to affected site as a liquid, gel, or paste. Alternatively, the polymer/drug combination can be injected ( intravenous, intraperitoneal, or subcutaneous) in an appropriate vehicle.

Cette invention se rapporte à des agents et à des procédés pour traiter les adhérences et les affections de type fibrose, grâce à la libération de médicaments qui retardent ou inhibent la production de tissu fibreux. Un procédé permettant de libérer à partir d'un polymère des agents inhibant les tissus fibreux est décrit. La combinaison polymère/médicament peut être appliquée directement sur la zone affectée, sous la forme d'un liquide, d'un gel ou d'une pâte. Dans une variante, la combinaison polymère/médicament peut être injectée (par injection intraveineuse, intrapéritonéale ou sous-cutanée) dans un excipient approprié.

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