Polymeric drug release system for medical devices

Details Polymeric drug release system for medical devices Polymeric drug release system for medical devices

A - Human Necessities

61

L

A61L 27/34 (2006.01) A61F 2/06 (2006.01) A61L 27/54 (2006.01) A61L 29/04 (2006.01) A61L 31/10 (2006.01) A61L 31/16 (2006.01)

Patent

CA 2534039

A coating composition comprising a mixture of a poly(vinylacetal-co- vinylalcohol-co-vinylacetate) and a poly(vinyl pyrrolidone-co-vinyl acetate) allows a medical device to be coated with a first layer containing a first bioactive (such as rapamycin) and a second layer containing a second bioactive (such as dexamethasone) for release in vivo at different release rates.

La présente invention se rapporte à une composition de revêtement, qui contient un mélange d'un poly(acétal de vinyle-co-alcool de vinyle-co-acétate de vinyle) et d'un poly(vinylpyrrolidone-co-acétate de vinyle). Ladite composition permet de revêtir un dispositif médical d'une première couche contenant un premier agent bioactif (tel que la rapamycine) et d'une seconde couche contenant un second agent bioactif (tel que la dexaméthasone), lesdits agents étant libérés in vivo à différentes vitesses de libération.

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