C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 14/00 (2006.01) C07K 14/705 (2006.01) C12N 15/10 (2006.01) C12N 15/62 (2006.01)
Patent
CA 2362373
The present invention identifies a domain located in the C.alpha.3 domain of IgA that is reponsible for targeting of the polymeric immunoglobulin receptor (pIgR) and transport of the antibody to the mucosal epithelium. This pIgR- binding domain may be used to target a wide variety of compositions, including proteins, nucleic acids, drugs and diagnositic agents, to the mucosal surface. Other more specific targeting agents may be used in conjunction with the pIgR- binding domain to define further the ultimate localization of the complexes in the body. Treatment of a large number of disease conditions such as viral, fungal and bacterial infections, as well as cancer, may be improved through the use of a pIgR-binding domain.
L'invention identifie un domaine situé dans le domaine C.alpha.3 de IgA chargé du ciblage du récepteur polymère d'immunoglobuline (pIgR) et du transport de l'anticorps vers l'épithélium mucosal. Le domaine de liant à pIgR peut être utilisé pour cibler une grande variété de compositions, notamment des protéines, des acides nucléiques, des médicaments, et des agents de diagnostic vers la surface mucosale. D'autres agents de ciblage plus spécifiques peuvent être utilisés en liaison avec le domaine se liant à pIgR afin de définir ensuite l'ultime localisation des complexes dans le corps. Le traitement d'un grand nombre de maladies telles que les infections virales, fongiques et bactériennes, ainsi que le cancer, peut être amélioré par utilisation d'un domaine se liant à pIgR.
Capra J. Donald
Hexham J. Mark
Mandecki Wlodeck
White Kendra
Bereskin & Parr Llp/s.e.n.c.r.l.,s.r.l.
Board Of Regents The University Of Texas System
Dgi Biotechnologies
Oklahoma Medical Research Foundation
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