Polymeric lamellar substrate particles for drug delivery

Details Polymeric lamellar substrate particles for drug delivery Polymeric lamellar substrate particles for drug delivery

A - Human Necessities

61

K

A61K 9/16 (2006.01) A61K 9/14 (2006.01) A61K 31/70 (2006.01) A61K 38/18 (2006.01) A61K 38/19 (2006.01) A61K 38/22 (2006.01) A61K 39/00 (2006.01) A61K 47/34 (2006.01) A61K 47/48 (2006.01) A61K 9/00 (2006.01)

Patent

CA 2223884

The invention provides a composition for delivery of an active agent comprising a plurality of lamellar particles of a biodegradable polymer which is at least in part crystalline, and an active agent adsorbed to at least most of the particles. Preferably the biodegradable polymer is at least 5 % by weight crystalline. Preferred biodegradable polymers are poly(L-lactide) (L.PLA) or copolymers or blends of L.PLA. The particles are especially useful for the immobilisation of antigens or allergens for vaccines.

Cette invention porte sur une composition permettant d'administrer un agent actif comportant plusieurs particules lamellaires d'un polymère biodégradable au moins partiellement cristallin ainsi qu'un agent actif adsorbé à la surface d'au moins la plupart de ces particules. Ce polymère biodégradable est, de préférence, de nature cristalline à au moins 5 % en poids. Les polymères biodégradables préférés sont des poly(L-lactide) (L.PLA) ou des copolymères ou des mélanges de L.PLA. Ces particules s'avèrent des plus efficaces pour immobiliser des antigènes ou des allergènes pour vaccins.

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