C - Chemistry – Metallurgy – 08 – B
Patent
C - Chemistry, Metallurgy
08
B
260/212, 252/23
C08B 15/06 (2006.01) C08B 37/02 (2006.01) C08B 37/12 (2006.01)
Patent
CA 1298578
POLYMERIC MATRIX FOR AFFINITY CHROMATOGRAPHY AND IMMOBILIZATION OF LIGANDS ABSTRACT A matrix useful for immobilizing organic ligands, such as biologically active materials, is prepared by reacting a hydroxyl group containing polymer with polyethyleneimine. Specifically, the matrix of the present invention is prepared by a process which includes the steps of reacting a hydroxyl containing polymer with 2-fluoro-1-methylpyridinium toluene-4- sulfonate (FMP) to form an activated polymer wherein at least some of the hydroxyl groups of the polymer have been substituted to form 1-methyl-2-pyridoxy toluene-4-sulfonate groups, and reacting the 1-methyl-2-pyridoxy substituted polymer with polyethyleneimine to form an affinity chromatographic matrix in which at least some of the 1-methyl-2-pyridoxy groups of the polymer have been replaced by polyethyleneimine.
552642
Oyen Wiggs Green & Mutala
Unisyn Fibertec Corporation
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