Polymeric micelle composition with improved stability

C - Chemistry – Metallurgy – 08 – L

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C08L 53/00 (2006.01) A61K 9/10 (2006.01) A61K 9/51 (2006.01)

Patent

CA 2463172

Polymeric compositions capable of forming stable micelles in an aqueous solution, comprising an amphiphilic block copolymer of a hydrophilic block and a hydrophobic block, and a polylactic acid derivative wherein one end of the polylactic acid is covalently bound to at least one carboxyl group. The carboxyl group of the polylactic acid derivative may be fixed with a di- or tri-valent metal ion, obtained by adding the di- or tri-valent metal ion to the polymeric composition.

Compositions polymères capables de former des micelles stables dans une solution aqueuse, comprenant un copolymère bloc amphiphile d'un bloc hydrophile et d'un bloc hydrophobe, et un dérivé d'acide polylactique, une extrémité de l'acide polylactique étant liée par covalence à au moins un groupe carboxyle. Le groupe carboxyle du dérivé d'acide polylactique peut être fixé par un ion métallique di- ou trivalent obtenu par adjonction d'un ion métallique di- ou trivalent à la composition polymère.

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