Polymeric microporous film coated subcutaneous implants

Details Polymeric microporous film coated subcutaneous implants Polymeric microporous film coated subcutaneous implants

A - Human Necessities

61

K

167/167

A61K 9/00 (2006.01) A61K 9/28 (2006.01) A61K 31/56 (2006.01) A61K 31/565 (2006.01) A61K 47/32 (2006.01) A61K 47/38 (2006.01)

Patent

CA 2304272

This invention relates to novel coating formulations for coating sustained- release drug implants. The coating formulations are capable of forming a porous film coat over a biologically active agent to provide release of the active agent at a constant rate over a prolonged period of time. The pore forming agent is used in the formulation of the invention in the amount effective to regulate the release of a biologically active compound at a desired rate. Preferably, the effective amount of the pore forming agent provides long term delivery of the active agent. The invention also provides an improved implant for the sustained administration of a biologically active compound suitable for subcutaneous implantation. The invention also relates to methods for making and using the formulation and the implant of the invention.

L'invention concerne de nouvelles formulations d'enrobage pour enrober des implants pharmacologiques à libération lente. Ces formulations d'enrobage peuvent former autour d'un agent bioactif une pellicule poreuse libérant le principe actif à un débit constant pendant une période prolongée. L'agent porogène est utilisé dans la formulation de l'invention en quantité effective pour réguler la libération d'un composé bioactif à un débit voulu. De préférence, la quantité effective de l'agent porogène assure une libération à long terme du principe actif. On décrit un implant amélioré destiné à l'administration lente d'un composé bioactif approprié pour une implantation sous-cutanée. On décrit enfin des procédés de production et d'utilisation de la formulation et de l'implant de l'invention.

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