Polymeric prodrug with a self-immolative linker

Details Polymeric prodrug with a self-immolative linker Polymeric prodrug with a self-immolative linker

A - Human Necessities

61

K

A61K 47/48 (2006.01) C08G 83/00 (2006.01) C08G 85/00 (2006.01)

Patent

CA 2602705

A cascade carrier linked prodrug is described which comprises a biologically active moiety and - a masking group having at least one nucleophile and being distinct from the carrier. In one preferred embodiment of the invention, the prodrug has the structure represented by formula (I).

L'invention concerne un promédicament lié à une porteuse en cascades comprenant une fraction active biologiquement, et un groupe de masquage présentant au moins un nucléophile et distinct de la porteuse. Dans un mode de réalisation préféré de l'invention, le promédicament présente la structure (F).

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