Polymeric salt delivery systems

A - Human Necessities – 61 – K

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A61K 9/10 (2006.01) A61K 9/66 (2006.01) A61K 9/70 (2006.01) A61K 31/505 (2006.01) A61K 47/48 (2006.01) A61L 26/00 (2006.01) A61L 27/00 (2006.01)

Patent

CA 2020966

- 22 - POLYMERIC SALT PHARMACEUTICAL DELIVERY SYSTEMS ABSTRACT OF THE DISCLOSURE A biocompatible, film-forming delivery system for the delivery of pharmaceutical or therapeutic actives to a desired topical site of a subject, the system including: an active salt compound, wherein the active salt com- pound is at least a partial salt of (1) a carboxylic acid moiety-containing, biocompatible, film-forming polymer with (2) at least one active selected from the group con- sisting of pharmaceutical actives, therapeutic actives and a combina- tion thereof, wherein the at least one active is capable of complexing with at least one carboxylic acid moiety of the polymer to form the active salt compound, and wherein the active salt compound forms an active salt compound film on the topical site and the active salt compound disas- sociates into the polymer and the at least one active while the deliv- ery system is in contact with the topical site such that the polymer remains thereon as a polymer film and the at least one active is deliv- ered to the topical site in an absorbable form. D-16096

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